Drug Category:
Other
Brand Name:
Seroquel
Generic Name:
Quetiapine
About Seroquel
(Quetiapine):
Brand name:
Seroquel Generic name: Quetiapine What is the most
important information I should know about seroquel?
Quetiapine is not for use in psychotic conditions
that are related to dementia. Quetiapine has caused
fatal pneumonia or heart failure in older adults with
dementia-related conditions. Stop using seroquel and
call your doctor at once if you have the following
symptoms: fever stiff muscles confusion sweating fast
or uneven heartbeats uncontrolled muscle movements
symptoms that come on suddenly such as numbness or
weakness severe headache and problems with vision
speech or balance. Quetiapine can cause side effects
that may impair your thinking or reactions. Be careful
if you drive or do anything that requires you to be
awake and alert. Avoid drinking alcohol which can
increase some of the side effects of seroquel. Avoid
using other medicines that make you sleepy (such as
cold medicine pain medication muscle relaxers and
medicine for seizures depression or anxiety). They
can add to sleepiness caused by seroquel. Avoid becoming
overheated or dehydrated. Drink plenty of fluids especially
in hot weather and during exercise. It is easier to
become dangerously overheated and dehydrated while
you are taking seroquel. What is seroquel? Quetiapine
is an antipsychotic medication. It works by changing
the actions of chemicals in the brain. Quetiapine
is used to treat the symptoms of psychotic conditions
such as schizophrenia and bipolar disorder (manic
depression). Quetiapine may also be used for purposes
other than those listed in this medication guide.
What should I discuss with my healthcare provider
before taking seroquel? Quetiapine is not for use
in psychotic conditions that are related to dementia.
Quetiapine has caused fatal pneumonia or heart failure
in older adults with dementia-related conditions.
Before taking seroquel tell your doctor if you have:
• liver disease; • kidney disease; • heart disease
high blood pressure heart rhythm problems; • a history
of heart attack or stroke; • a thyroid disorder; •
seizures or epilepsy; • high cholesterol or triglycerides;
• a personal or family history of diabetes; or • trouble
swallowing. If you have any of these conditions you
may not be able to use seroquel or you may need a
dosage adjustment or special tests during treatment.
Quetiapine may cause you to have high blood sugar
(hyperglycemia). Talk to your doctor if you have any
signs of hyperglycemia such as increased thirst or
urination excessive hunger or weakness. If you are
diabetic check your blood sugar levels on a regular
basis while you are taking seroquel. FDA pregnancy
category C. This medication may be harmful to an unborn
baby. Tell your doctor if you are pregnant or plan
to become pregnant during treatment. It is not known
whether seroquel passes into breast milk or if it
could harm a nursing baby. Do not use this medication
without telling your doctor if you are breast-feeding
a baby. How should I take seroquel? Take this medication
exactly as it was prescribed for you. Do not take
the medication in larger amounts or take it for longer
than recommended by your doctor. Your doctor may occasionally
change your dose to make sure you get the best results
from this medication. Take each dose with a full glass
of water. It is important to take seroquel regularly
to get the most benefit. Do not take seroquel for
longer than 6 weeks unless your doctor has told you
to. To be sure this medication is helping your condition
your doctor will need to check your progress on a
regular basis. It is important that you not miss any
scheduled visits to your doctor. Store seroquel tablets
at room temperature away from moisture and heat. What
happens if I miss a dose? Take the missed dose as
soon as you remember. If it is almost time for your
next dose skip the missed dose and take the medicine
at the next regularly scheduled time. Do not take
extra medicine to make up the missed dose. What happens
if I overdose? Seek emergency medical attention if
you think you have used too much of this medicine.
Symptoms of a seroquel overdose may include extreme
drowsiness fast heart rate feeling light-headed or
fainting. What should I avoid while taking seroquel?
Quetiapine can cause side effects that may impair
your thinking or reactions. Be careful if you drive
or do anything that requires you to be awake and alert.
Dizziness may be more likely to occur when you rise
from a sitting or lying position. Rise slowly to prevent
dizziness and a possible fall. Avoid drinking alcohol
which can increase some of the side effects of seroquel.
Avoid using other medicines that make you sleepy (such
as cold medicine pain medication muscle relaxers and
medicine for seizures depression or anxiety). They
can add to sleepiness caused by seroquel. Avoid becoming
overheated or dehydrated. Drink plenty of fluids especially
in hot weather and during exercise. It is easier to
become dangerously overheated and dehydrated while
you are taking seroquel. What are the possible side
effects of seroquel? Get emergency medical help if
you have any of these signs of an allergic reaction:
hives; difficulty breathing; swelling of your face
lips tongue or throat. Stop using seroquel and call
your doctor at once if you have any of these serious
side effects: • fever stiff muscles confusion sweating
fast or uneven heartbeats; • jerky muscle movements
you cannot control; • sudden numbness or weakness
especially on one side of the body; • sudden headache
confusion problems with vision speech or balance;
• increased thirst frequent urination excessive hunger
or weakness; • thoughts of suicide or hurting yourself;
• feeling light-headed fainting; or • urinating less
than usual or not at all. Continue taking seroquel
and talk to your doctor if you have any of these less
serious side effects: • dizziness drowsiness or weakness;
• dry mouth runny nose sore throat; • nausea vomiting
stomach pain constipation; • blurred vision headache
anxiety agitation; • sleep problems (insomnia); •
breast swelling or discharge; • missed menstrual periods;
or • weight gain. Side effects other than those listed
here may also occur. Talk to your doctor about any
side effect that seems unusual or that is especially
bothersome. What other drugs will affect seroquel?
Before taking seroquel tell your doctor if you are
taking any of the following medicines: • cimetidine
(Tagamet); • lorazepam (Ativan); • rifabutin (Mycobutin)
or rifampin (Rifadin Rimactane Rifater); • steroids
(prednisone and others); • thioridazine (Mellaril);
• an antibiotic such as erythromycin (E-Mycin E.E.S
Ery-Tab) fluconazole (Diflucan) ketoconazole (Nizoral)
itraconazole (Sporanox); • medicine for depression
or mentail illness such as fluoxetine (Prozac) haloperidol
(Haldol) imipramine (Torfanil) or risperidone (Risperdal);
• a medication to treat high blood pressure or a heart
condition; or • seizure medication such as carbamazepine
(Tegretol) divalproex (Depakote) phenobarbital (Luminal
Solfoton) phenytoin (Dilantin) or valproate (Depakene).
If you are using any of these drugs you may not be
able to use seroquel or you may need dosage adjustments
or special tests during treatment. There may be other
drugs not listed that can affect seroquel. Tell your
doctor about all the prescription and over-the-counter
medications you use. This includes vitamins minerals
herbal products and drugs prescribed by other doctors.
Do not start using a new medication without telling
your doctor.
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Synonyms:
Seroquel (Quetiapine)
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Prescription drug spending was flat in 2011
Spending on prescription drugs in the U.S. was nearly flat in 2011 at $320 billion, held down by senior citizens and others reducing use of medicines and greater use of cheaper generic pills. Last year, spending on prescription drugs rose just 0.5% after adjusting for inflation and population growth, according to data firm IMS Health. Without those adjustments, spending increased 3.7% last year. The volume of prescriptions filled fell about 1%.
That continues a trend of restrained spending that began in 2007, when prescription spending dipped 0.2%. Before then, IMS generally reported annual spending increases of several percent. But since the start of the Great Recession, prescription spending has fallen or risen only slightly each year except for 2009. IMS said Wednesday that it appears patients are still rationing their health care, with visits to doctors down 4.7% and hospital admissions down 0.1%. However, emergency room visits jumped 7.4%, a sign some people aren't seeking care until they are very sick.
"We think we've reached a tipping point, where people are thinking they're paying too much and they're changing their behavior" and getting less treatment, said Michael Kleinrock, head of research development at the IMS Institute for Healthcare Informatics. Fewer visits to doctors and other health care providers results in fewer prescriptions, which holds down spending in the short term. But that doesn't bode well for future health care costs, because many of the medicines people are doing without are taken for years to prevent heart attacks and other expensive complications of chronic conditions such as heart disease and diabetes, Kleinrock said.
"The ultimate result is that we will have more sick people driving health care costs" down the road, he said.
People age 65 and older cut back on the number of prescriptions filled by 3.1% last year, particularly for medicines for high blood pressure. That was despite a 10% decline in average prescription co-payments under the Medicare Part D program, to $23.31, due to bigger discounts when patients hit the so-called doughnut hole coverage gap.
Only one group increased prescription use last year. People age 19 to 25, now able to stay on their parents' health insurance plans under a provision of the Patient Protection and Affordable Care Act, boosted their use of prescription medicines 2%. That was led by more use of antidepressants and attention deficit disorder drugs.
Kleinrock noted the data indicate people with and without insurance are all having trouble paying for medicine and other health care, and so are limiting or postponing treatment. For instance, insured patients spent $1.8 billion less out of pocket last year, at a total of $49 billion.
Meanwhile, use of inexpensive generic medicines continues to climb, hitting 80% of all prescriptions filled last year. That growth is fueled both by patients trying to save money and by the start of an avalanche of blockbuster medicines, many for chronic conditions, losing patent protection.
Cholesterol fighter Lipitor, the top-selling drug in history with a $13 billion-a-year peak, got its first U.S. generic competition Nov. 30. This year, generic competition arrives for drugs taken by millions of people for high blood pressure, diabetes, asthma and allergies, depression, schizophrenia and prevention of blood clots that can cause heart attacks and strokes.
The institute's annual report shows patient restraint and increased use of generics are offsetting factors that usually push up spending on prescriptions significantly, particularly use of pricey, newly approved medications.
Last year, 34 new prescription medications were launched in the U.S., the most in a decade. They brought significantly better treatments to more than 20 million Americans with life-threatening conditions, including cancer, hepatitis C, heart disease and multiple sclerosis. But the new drugs carry big price tags, with most costing tens of thousands of dollars for a year or a course of treatment.
Prescription drug revenue also was boosted by price increases for existing medications and by the newly insured young adults.